Scientists of Pitirim Sorokin Syktyvkar State University have developed a publicly available ChronobioticsDB database that systematizes information about chronobiotics. These are substances that affect human biological rhythms, including sleep. According to the press service of the Ministry of Education and Science of the Russian Federation, this is the first resource of this kind in the world, created as part of the project of the Russian Science Foundation “Creation of the world’s first pharmacological database of circadian rhythm modulators and organization of access to it.”
The database contains information about more than 300 natural and artificially synthesized substances that have been studied in recent decades, such as melatonin and resveratrol. They can affect circadian rhythms, sleep, and wakefulness. When biological clocks get disrupted, it can lead to insomnia, chronic fatigue, impaired concentration, libido decline, as well as serious illnesses.
Ilya Solovyov, the project manager, added that ChronobioticsDB provides convenient search tools: each drug has a card with its chemical formula, mechanism of action, potential use and side effects. A special feature of the database is its integration with international chemical and pharmaceutical databases such as PubChem and DrugBank, as well as the option of checking the registration status of the substances.
The developers are confident that their product will help doctors choose therapies for sleep disorders, and researchers will find new and effective drugs that can reset the body clock back to normal. The database is already available for free use by the academic community and medical professionals.
Earlier, it was reported that scientists at the Center for Mathematical Modeling in Drug Development at Sechenov University have created and registered the first database containing information on the side effects of checkpoint inhibitors and their combinations in immunooncological drugs. This is an advanced class of drugs that have changed the approach to cancer treatment.
