Researchers at Perm National Research Polytechnic University (PNRPU) have developed a new class of organic compounds with a pronounced analgesic effect and minimal toxicity. The PNRPU press service reported that, according to the university’s press service, these substances can form the basis of a new generation of analgesics with minimal side effects. The study’s findings were published in the Russian Chemical Journal (2025).
PNRPU scientists worked on the project together with colleagues from the Perm State Pharmaceutical Academy (PSPA) of the Ministry of Health of the Russian Federation, ITMO, Perm State National Research University (PSNRU), and Nizhny Novgorod State University (NNSU).
As a result of their work, a new class of compounds has been synthesized — N-Alkyl-4-aryl-2-aroylhydrazylidene-4-oxobutanamides, which can become the basis for the creation of promising drugs. During the synthesis, scientists obtained several types of derivatives in the form of soluble colorless crystals.
To test the properties of the new product, they conducted experiments on laboratory mice. The animals were injected with compounds in the form of a suspension. Then, they were placed on a heated plate, and the time was measured until they exhibited a painful reaction (such as attempting to escape or licking their paws). The experimental group’s pain reaction time increased twofold compared to the control group. In addition, studies have shown that even at high doses, the substances remain practically safe.
“The product demonstrates a strong analgesic effect with low toxicity, which makes it promising for further research,” said Ekaterina Denislamova, Associate Professor of the Department of Chemical Technologies at PNRPU, Candidate of Sciences in Chemistry.
The scientists emphasized that these compounds are an important step in the development of Russian pharmacology due to their simplicity of synthesis, low toxicity even in high doses, safety, and pronounced medicinal properties.
Earlier it became known that researchers from the Russian Technological University (RTU MIREA) had created photo-switchable drugs (pharmaceutical substances) that can be activated in the body and desactivated after the desired effect is achieved. The development will reduce the risks of side effects of drugs.
