Scientists from Tomsk Polytechnic University, together with colleagues from Siberian State Medical University (SibSMU) and the A.V. Nikolaev Institute of Inorganic Chemistry, have synthesized a previously unknown organic compound based on benzoxazole that can inhibit the growth of cancer cells. This was reported by the press service of the Russian Ministry of Education and Science.
The compound 2-(3-(fluorosulfato)phenyl)benzoxazole not only has cytostatic properties against cancer cells, meaning it suppresses their division and growth, but is also capable of glowing.
“The integration of cytostatic properties with fluorescent characteristics opens up unique opportunities for using the new compound in chemical biology, molecular diagnostics, and personalized medicine, for example, for real-time monitoring,” believes the project leader, Nadezhda Danilenko. According to her, the combination of such qualities will help to better understand the interaction of drugs with cells and develop effective targeted treatment methods.
The synthesized benzoxazole derivatives were successfully tested in vitro on cell lines of prostate and breast adenocarcinoma. “The research results showed that the biological activity of the new compounds makes them promising for developing drugs to slow malignant neoplasms growth,” the report says.
Earlier studies have shown that the occurrence of certain types of cancer, including adenocarcinoma, is associated with excess body weight. GxP News investigated whether this connection is direct and whether people can avoid cancer by losing weight.