Russian scientists have developed an innovative technology to protect and restore the liver using biocompatible nanoparticles and microRNA molecules. Researchers from Sechenov University, Privolzhsky Research Medical University (PIMU), ITMO University and the Moscow Institute of Physics and Technology (MIPT) collaborated on the project, GxP News reported.
The technology relies on nanoparticles made from polylactic acid and auxiliary polymers. These nanoparticles act as carriers for microRNA-200a molecules, shielding them from degradation in the bloodstream and ensuring gradual release directly inside liver cells.
MicroRNA-200a plays a key role in regulating genes responsible for oxidative stress, inflammation and tissue damage, the researchers stressed. In liver disease, this regulatory mechanism breaks down, promoting the development of fibrosis and liver failure.
“Developing a microRNA-based therapy allows us to target several key points in the disease process simultaneously,” said Pyotr Timashev, scientific director of the Sechenov University Biomedical Science and Technology Park. “This study confirmed the protective effect of these molecules in both acute and chronic liver injury.”
According to Timashev, the approach not only reduces the severity of pathological changes but also activates the body’s natural tissue repair processes.