Perm scientists have suggested a promising method for isolating DNA fragments from salmon fish milk with a product yield of more than 5%. The bioactive molecules obtained can become the basis for medicines, dietary supplements, and anti-aging skincare products. This was reported by the press service of Perm Polytechnic University. The research is published in the collection “Youth Science — 2025: technologies and innovations”.
Russian researchers have developed an economical technology for extracting bioactive DNA fragments from fish milk, a byproduct of the fishing industry. The method, which uses the enzyme trypsin, allows for the isolation of up to 5.65% of DNA from the initial weight of the milk.
DNA molecules serve as a source of polynucleotide fragments known as PDRNs (polydeoxyribonucleotides), which exhibit various biological activities. These compounds, with molecular weights ranging from 50 to 1,500 kDa, promote cell growth and differentiation, enhance wound healing, and stimulate tissue repair. Specific nucleotide sequences are recognized by immunocompetent cells and can stimulate the immune system.
“PDRN is used as a commercial drug for tissue repair and wound treatment in South Korea and Italy. The researchers note that this potential has not yet been realized in Russia, despite the fact that fish milk could become an affordable and inexpensive raw material for the production of biomedical products.
Further research by scientists aims to assess the composition of the obtained extract, including its lipid, amino acid, and polyamine content, as well as to explore potential practical applications of the product.
