Natsimbio, a holding company within state corporation Rostec, has received a registration certificate from Russia’s health ministry for the vaccine aDTP-M for the prevention of whooping cough, diphtheria and tetanus in individuals over 18 years of age. The drug was developed by immunobiological drug manufacturer Microgen, part of Natsimbio, using an acellular pertussis component, making it suitable for adult booster vaccination. According to the developer, a single dose provides immunity for up to 10 years.
Natsimbio believes that having full-cycle domestic production could justify including the vaccine in the National Preventive Vaccination Calendar and introducing regular adult booster shots every 10 years.
The holding’s production capacity allows for up to 5 million doses per year, with potential for further expansion. As noted by Rostec deputy general director Alexander Nazarov, within a year the facility will be able to fully meet the current needs of the Russian market for this vaccine. According to him, previously drugs with a similar composition were supplied exclusively by foreign manufacturers.
Clinical trials were conducted at 10 research centres involving 436 volunteers aged 18 to 60. After one month, most participants had developed protective antibody titres against all three infections, with good or very good tolerability reported. Studies involving children are planned in the near future.
Whooping cough remains a significant problem for Russian healthcare: in 2024, incidence exceeded the long-term average by 4.5 times, and in 2023 by 7.6 times, with adults increasingly involved in the epidemic process. The development of the first domestic vaccine against diphtheria, tetanus and whooping cough for adults became known in 2025. At that time, Natsimbio noted that previously there had been no domestic analogue of a three-component vaccine for the prevention of these infections in adults. The uniqueness of the aDTP-M vaccine lies in its reduced concentrations of diphtheria and tetanus toxoids and an acellular pertussis component.
